Hyperuricosuria – test validated for Schapendoes!

Clinical validations of hyperuricosuria in Schapendoes are now complete and we have concluded, that the mutation causing hyperuricosuria in many breeds causes disease also in Schapendoes. The DNA-test for hyperuricosuria is included in the MyDogDNA testing panel for Schapendoes.

Hyperuricosuria predisposes affected dogs to the formation of uric acid stones throughout the upper and lower urinary tracts, including the urethra, bladder, ureters, and kidneys. Clinical signs of urolithiasis in the lower urinary tract include pain while urinating, bloody urine, and blockage of the urinary tract. Patients with urine stones are more susceptible to urinary tract infections. Blockage of the ureters and kidneys causes abdominal pain and kidney failure. A blocked urinary tract is a life-threatening condition that requires immediate veterinary care. Males are more likely to form stones than females.

Hyperuricosuria is inherited in an autosomal recessive manner. The underlying genetic defect can be found by genetic testing from a dog of any age. The test differentiates the dog as normal, carrier or affected. Dogs carrying the disease are not affected by the disease but may pass the genetic defect to their offspring.

Breeds affected by hyperuricosuria can be seen here: http://www.mybreeddata.com/crm/index.html#disorder/051_SLC2A9/

 

Genoscoper research team