Soon in the MyDogDNA test panel: Developmental Syndrome in Wire Fox Terriers

The genetic cause for a previously undescribed skeletal syndrome in Wire Fox Terriers was recently revealed in a publication by the canine genetics research group at the University of Helsinki. Genoscoper will soon be the first laboratory in the world to offer the genetic test for this condition in the MyDogDNA test panel.

More information on the disorder:

Developmental Syndrome in Wire Fox Terriers (Van den Ende-Gupta)

A skeletal syndrome causing severe skeletal anomalies has been described in Wire Fox Terriers. The disorder causes multiple skeletal defects with the most common being severe patellar luxation and severe underbite. The mode of inheritance is autosomal recessive. The genetic defect is estimated to be relatively common within the breed. In one study, 22% of the control population were carriers of the disorder.

Clinical overview

The disorder causes multiple skeletal anomalies that are already evident in young puppies. Severe underbite is often noticed as the first sign of the disorder. Another characteristic feature of the disorder is severe patellar luxation. Patellar luxation causes alteration in gait, hind-limb-lameness and “bouncing” of the affected leg. Bilateral patellar luxation can sometimes only be seen as abnormal gait, reluctance to move, jump or climb stairs. The disorder can also cause many other skeletal changes, such as elbow luxation, abnormal structure of the nasal septum, rib changes, spinal changes and abnormal bone mineralization and ossification. Affected dogs can also have abnormally small eyes and thin sclera.

Clinical signs

  • Severe underbite
  • Severe patellar luxation
  • Other skeletal defects