Blood disorders

A novel variant in the VWF gene is associated with von Willebrandt Disease Type II

Von Willebrand disease is the most common inherited bleeding disorder in dogs, caused by deficient or defective plasma von Willebrand Factor (vWF), a blood clotting protein. Five different genetic variants in the vWF encoding gene have been previously associated to different forms of vWD: Type I, Type II and Type III in dogs. The study published earlier this month, suggest a novel variant as a candidate causal variant for vWD Type II in German Shorthaired Pointer and German Wirehaired Pointer (Vos-Loohuis M et al., 2017).