The genetic differentiation of dog breeds has led to alterations in metabolism

A recently published article shows that canine breeds can be distinguished by alterations in their lipidome. The study of Lloyd et al. (2017) examined lipidome differences in 100 dogs from 9 different breeds. The study showed distinct inter-breed differences in the breeds’ lipidomes. This study highlights that the genetic differentiation of dog breeds has resulted in alterations in metabolism.

Breed-Defining Chondrodysplasia

Breed-defining chondrodysplasia, also called short-leggedness, is a favorable phenotype found in some breeds. The well-known features of this breed-defining trait are caused by the FGF4 retrogene insertion. Short-leggedness caused by the FGF4 insertion is a desirable trait, and it is caused by different mutation than the undesired dwarfism causing genetic disorder found in some breeds, such as the Norwegian Elkhound.