MyDogDNA research

A novel variant in the VWF gene is associated with von Willebrandt Disease Type II

Von Willebrand disease is the most common inherited bleeding disorder in dogs, caused by deficient or defective plasma von Willebrand Factor (vWF), a blood clotting protein. Five different genetic variants in the vWF encoding gene have been previously associated to different forms of vWD: Type I, Type II and Type III in dogs. The study published earlier this month, suggest a novel variant as a candidate causal variant for vWD Type II in German Shorthaired Pointer and German Wirehaired Pointer (Vos-Loohuis M et al., 2017).

Kystinuriatutkimus – Osallistu tutkimukseen!

Kystinuria on perinnöllinen sairaus, joka aiheuttaa kystiinikivien muodostumista virtsateihin. Virtsakivet aiheuttavat kivuliasta virtsaamista, verivirtsaisuutta ja virtsatietukoksia. Virtsatietukos on hengenvaarallinen tila, joka vaatii nopeaa eläinlääkärihoitoa. Kystiinikiviä tavataan lähinnä uroskoirilla (98% sairastuneista uroksia).

The dog, the DNA test, and the scientist – a reflection on four years of panel screening

When we first launched the MyDogDNA® (Optimal Selection™ in the United States) DNA test in 2013, we took a giant leap into unexplored territory. To be honest (and we Finns typically are), pioneering a whole new way of thinking about dog DNA testing was not the easiest thing to do. 

If you had been able to listen in on the conversations at our laboratory office back then, you would probably have heard us asking ourselves questions such as: 

MyDogDNA research update: Novel carrier findings in Lagotto Romagnolo, Papillon, Brazilian Terrier and Danish-Swedish Farmdog breeds

Comprehensive panel testing of genetic mutations known to underlie canine inherited disorders offers an efficient and powerful opportunity to screen for presence of mutations across breeds. This enables discovery of previously unreported mutations in breeds that would not necessarily have been screened for the mutations otherwise. However, whether these mutations actually manifest similarly as described in the original breeds requires always further scientific investigation in the new breeds involving clinical characterization of genetically affected individuals.