When we first launched the MyDogDNA® (Optimal Selection™ in the United States) DNA test in 2013, we took a giant leap into unexplored territory. To be honest (and we Finns typically are), pioneering a whole new way of thinking about dog DNA testing was not the easiest thing to do.
If you had been able to listen in on the conversations at our laboratory office back then, you would probably have heard us asking ourselves questions such as:
The hard work of our R&D has recently resulted in the new and even more comprehensive MyDogDNA® 2016 test panel that is available in our web shop. For dogs that have already been tested with MyDogDNA PASS, MyDogDNA LITE or MyDogDNA 2015 packages, we offer the possibility for cost-efficient upgrade for purchasing the new test content. The upgrade requires a new sample.
Many different types of hereditary bleeding disorders have been encountered in dogs, some of which are quite common in certain breeds (Table 1). Most of these cause spontaneously only mild bleeding, such as nosebleeds or bleeding of the gums. However, many bleeding disorders can cause excessive, even life-threatening, bleeding after surgery or trauma.
Table 1. The occurrence of certain common bleeding disorders in certain breeds
New study on the canine breed disease heritage gives a comprehensive insight into the breed distribution of disease related genetic risk variants
The MyDogDNA research team of Genoscoper Laboratories Oy, Finland, has in collaboration with scientists from the University of Helsinki, Finland, and University of Pennsylvania, Philadelphia, USA, published the results from the most comprehensive investigation into the canine breed disease heritage to date.
The MyDogDNA test panel includes now a new genetic test for coat colors: The a allele in the color locus A. The result is available to all MyDogDNA 2015 tested dogs on the "Traits" tab.
The A-locus, also known as the ASIP gene, affects the production of the pigment molecule responsible for black color. Four different alleles are known at the A locus: ay, aw, at and a allele.
Domestic dogs have great diversity in white spotting patterns ranging from extreme white to minimal white or completely solid color. The amount of white color is determined by genetic factors as well as by stochastic events in pigment cell development. It is important to understand that white color in domestic dogs is controlled by many variants as well as random events in the maturation of the cells.
The intensive work of our Research and Development staff results now in a new and even more comprehensive MyDogDNA® 2015 test panel. MyDogDNA® 2015 will be available in our web shop the coming week. For dogs that have already been tested with MyDogDNA PASS or MyDogDNA LITE packages, we are able to offer cost-efficient upgrades for purchasing the new test content. The upgrade requires a new sample.
Panel Testing of Canine Inherited Disorders Provides Great Opportunities, But Requires a New Level of Information Management
The number of canine genetic tests available to breeders and veterinarians has increased radically over the past 10 years in the wake of new discoveries made by research groups. Following this development, several DNA testing laboratories have restructured their services to move from one-by-one single gene tests to offering multiple disorder or trait tests at once. Such services are typically offered as “combination packages”, “multiplex or panel tests”, or a “smorgasbord” where the consumer picks the desired gene tests.
The world’s most complex and comprehensive genetic test for dogs, MyDogDNA, has been available to all dog owners for about a year. During this time, Lagottos have been tested to the extent that it is possible to get an overview of the genetic variation in the breed. The Lagotto enthusiasts have also gratifyingly adopted the MyDogDNA Breeder –tool that is based on the test results in the MyDogDNA database in order to treasure the breed’s genetic diversity.
Uncovering the true breed distribution of mutations causing inherited disorders - Novel research findings for American Foxhound, Japanese Spitz, Miniature Schnauzer, Norrbottenspitz, and Sealyham Terrier
Canine genetics research is advancing rapidly, with around 180 mutations underlying monogenic inherited disorders and traits discovered to date. However, most original studies are focused on one or a few breeds, with a limited number of screened reference dogs from additional breeds. Such approaches are efficient for initial discovery of a mutation, enabling development of a gene test for breeders. Knowledge on the true distribution of the mutation across breeds nevertheless often remains incomplete at the time of the initial discovery.
Introduction to MyDogDNA panel testing of canine inherited disorders and reporting of the test results
Approximately 600 inherited disorders and traits have been described in dogs. Currently, around 160 of these can be tested for due to mutation discoveries made by, and single-gene tests developed by different canine genetics research groups. MyDogDNA provides the first available panel testing concept combined with a research approach that helps breeders and researchers study the presence and distribution of known inherited disorders across dog breeds, while simultaneously providing any dog owner with a possibility to get results for the tested disorders known in their breed.