Dilated Cardiomyopathy (DCM) is a severe hereditary disorder present in Doberman Pinschers and other breeds that ultimately leads to heart failure and sudden death.
Kromfohrländer, a native German breed, is known to have a very limited gene pool and is thus subject to a cross-European breeding project focusing to expand the pool. Given the vulnerable genetic status of the breed, the Finnish Breed Association for Kromfohrländer initiated a project aiming at measuring the genome-wide diversity of the breed in 2013. Several dogs of Central European origin were also recruited for the study.
Originally, Akita Inu is an ancient Japanese hunting breed that has a variety of different phases in its history. Nowadays, there are tens of thousands of Akita Inus, most of them living in the breed's country of origin, Japan. The breed has developed from a small number of dogs. As a result, the breed has a narrow gene pool and therefore, the owners and breeders of Akita Inus share now a common goal to preserve the breed's genetic diversity.
We have received a lot of questions regarding the new storage disease test for Lagottos.
The Canine Genetics Research Group at the University of Helsinki has published today information about new testing possibilities within the ongoing study.
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Coat Furnishings (moustache and eyebrows) / Improper Coat in Portuguese Water Dogs, variant chr13:11659792
Coat Furnishings (moustache and eyebrows) / Improper Coat in Portuguese Water Dogs, variant chr13:11676852
This test is based on two genetic variants whose presence in the dog's genome is strongly associated with the furnishings phenotype.
A year ago we lived exciting times. The MyDogDNA pilot project, the very first dog's genome-wide panel testing and diversity analysis was about to start later in the Spring. Close to 2000 dogs from 50 breeds participated in the analysis. The pilot project not only gave birth to a whole new DNA testing service and platform, but to a whole new forward-thinking community of dog owners, breeders and Breed Clubs. Now, a year later, the second release of MyDogDNA testing concept is at hand.
Even if the “popular sire” in this essay is chosen on a dog show, what is said is also true for breeding working dogs. Because here as well the most successful performance dog will be used for breeding more than average, which could result e.g. in several thousand offspring sired by a big winning track racing Greyhound.
Ahead of the New Year, we want to provide you with a quick overview to the genome-wide measured diversity levels in various breeds. The brief listing helps you quickly get an understanding of the kind of differences there may be between the pedigreed breeds in terms of the measured heterozygosity.
The Samoyed takes its name from the Samoyedic people, an Asiatic group of nomadic origins living in Siberia. These reindeer herders bred the fluffy white dogs to help with the herding, and to pull sleds when they moved. In Europe, the breed is known also as Bjelkier. In Russian, the dogs are called Voinaika which means lead or direction dog or guard, hunting and war dog.
MyDogDNA research update: Novel carrier findings in Lagotto Romagnolo, Papillon, Brazilian Terrier and Danish-Swedish Farmdog breeds
Comprehensive panel testing of genetic mutations known to underlie canine inherited disorders offers an efficient and powerful opportunity to screen for presence of mutations across breeds. This enables discovery of previously unreported mutations in breeds that would not necessarily have been screened for the mutations otherwise. However, whether these mutations actually manifest similarly as described in the original breeds requires always further scientific investigation in the new breeds involving clinical characterization of genetically affected individuals.
The most common admonition of the geneticist to the dog breeder is to "avoid the Popular Sire Syndrome". At the same time, the most common advice from breeder to breeder is to breed "the best to best". So the conundrum is obvious and the consequence predictable - the "best" dogs are the most sought after, so they sire the most offspring and become popular sires.
Introduction to MyDogDNA panel testing of canine inherited disorders and reporting of the test results
Approximately 600 inherited disorders and traits have been described in dogs. Currently, around 160 of these can be tested for due to mutation discoveries made by, and single-gene tests developed by different canine genetics research groups. MyDogDNA provides the first available panel testing concept combined with a research approach that helps breeders and researchers study the presence and distribution of known inherited disorders across dog breeds, while simultaneously providing any dog owner with a possibility to get results for the tested disorders known in their breed.
Ear erectness (pricked ears versus floppy ears), variant chr10:11072007
MyDogDNA genome-wide analysis identifies carriers of a known bleeding disorder in Finnish Hounds and Welsh Springer Spaniels
Canine disease genomics progresses quickly and academic research groups around the world have already discovered mutations underlying more than 160 genetic disorders and traits in different breeds. Until today, testing of the known canine diseases has been possible only with separately conducted single-gene tests. Genoscoper Laboratories has, as the first animal diagnostics laboratory in the world, developed a unique genetic panel testing and reporting concept to efficiently and economically test most of the known mutations at once.
A warm thank you to all of you who visited our stand at the European Dog Show 2013 in Geneva and showed such a big interest towards the very first MyDogDNA Research Programme, the new MyDogDNA Pass as well as the first truly global dog DNA database. We were pleased to meet both our existing customers as well as many new show dog enthusiasts! Your useful feedback will guide us further with the development of both the MyDogDNA Pass and the MyDogDNA Breeder, the first dog matchmaking tool built on top of the analysed data.