Sealyham Terrier

Breed-Defining Chondrodysplasia

Breed-defining chondrodysplasia, also called short-leggedness, is a favorable phenotype found in some breeds. The well-known features of this breed-defining trait are caused by the FGF4 retrogene insertion. Short-leggedness caused by the FGF4 insertion is a desirable trait, and it is caused by different mutation than the undesired dwarfism causing genetic disorder found in some breeds, such as the Norwegian Elkhound.

Understanding the Dog's Genetic Size Facilitates Planning Individual Care and Weight Control

MyDogDNA has now added four new size associated genetic markers called GHR1, GHR2, HMGA2, STC2and a test for breed-defining chondrodysplasia to the test panel. These markers, together with the previously reported size associated markers in IGF1 and IGF1R give more information on the dog size, supporting finer prediction of the genetic size of a dog.

Uncovering the true breed distribution of mutations causing inherited disorders - Novel research findings for American Foxhound, Japanese Spitz, Miniature Schnauzer, Norrbottenspitz, and Sealyham Terrier

Canine genetics research is advancing rapidly, with around 180 mutations underlying monogenic inherited disorders and traits discovered to date. However, most original studies are focused on one or a few breeds, with a limited number of screened reference dogs from additional breeds. Such approaches are efficient for initial discovery of a mutation, enabling development of a gene test for breeders. Knowledge on the true distribution of the mutation across breeds nevertheless often remains incomplete at the time of the initial discovery.