New test content available in MyDogDNA/Optimal Selection reports: Lung Developmental Disease in Airedale Terriers

Research performed in Professor Hannes Lohi’s canine genetics research laboratory at the University of Helsinki and Folkhälsan Institute of Genetics, Helsinki, Finland has led to the discovery of a genetic mutation responsible for Lung Developmental Disease in Airedale Terriers. The work was funded in part by Wisdom Health and Genoscoper Laboratories, providers of the MyDogDNA™ (Europe) / Optimal Selection™ (United States) test.

Lung Developmental Disease in the Airedale Terrier is characterized by lethal hypoxic respiratory distress and failure. Affected puppies start having difficulties breathing within the first days or weeks of life, and typically pass away or are euthanized after the onset of respiratory symptoms. Lung Developmental Disease in Airedale Terriers is caused by surfactant dysfunction due to a defect in the surfactant producing organelles of the lung epithelial. Pulmonary surfactant is essential for lung function as it reduces the surface tension and prevents the alveoli, the gas exchange compartment of the lungs, from collapsing.

The causative gene for lung disease in Airedale Terriers was identified as LAMP3. The discovered mutation is inherited in an autosomal recessive manner, and so far found to be present only in Airedale Terriers with a breed carrier frequency of 20%. The detailed results of the study are published in a peer-reviewed scientific article that can be found here.

This mutation discovery has enabled the development of a genetic test for Lung Developmental Disease in Airedale Terriers to allow management of the condition in breeding programs, so that healthy carrier dogs can be kept in the gene pool while avoiding affected offspring.

In addition to the novel Lung Developmental Disease test, the MyDogDNA™/Optimal Selection™ screening for Airedale Terriers also includes testing for Degenerative Myelopathy (DM), Protein Losing Nephropathy (PLN), Hyperuricosuria (HUU), Factor IX Deficiency (Hemophilia B), and Factor VII Deficiency. Additional test results for inherited traits (e.g., coat color, coat type and body size) and genetic diversity level are also included. 

For ordering tests and to learn more about genetic tests available for your breed of interest, please visit: MyDogDNA (Europe) or Optimal Selection™ (United States).